Linked Life Data

6891913

Source:http://linkedlifedata.com/resource/pubmed/id/6891913

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-5-27
pubmed:abstractText
Studies in vitro suggest that pregnancy induced hypertension, or toxemia, is associated with decreased placental prostaglandins E (PGE) levels. To validate this observation in vivo PGE were measured weekly in 24h urine collections, in a prospective cross-sectional study in 9 women from 7 to 40 weeks. In addition, urinary PGE levels were also measured in 28 hospitalized pregnant women with either chronic hypertension or toxemia. Prostaglandins E were measured by radioimmunoassay after organic extraction and silicic acid separation. Urinary PGE levels during pregnancy (normotensive and chronic hypertensive women) were significantly elevated than those of the non-pregnant state. Mean urinary PGE levels in toxemic patients were significantly decreased compared to those of normal pregnancy and patients with chronic hypertension but they were similar to the mean levels of the non-pregnant state. One fetal death attributed to aggravation of chronic hypertension and one eclampsia were associated with undetectable levels of maternal urinary PGE. In conclusion, normal pregnancy is associated with a significant increase of urinary PGE; chronic hypertension and occurrence of toxemia are associated with significant diminution of urinary PGE excretion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0730-0085
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
539-52
pubmed:dateRevised
2008-3-4
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
A prospective study of urinary prostaglandins E in women with normal and hypertensive pregnancies.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't