Linked Life Data

6891244

Source:http://linkedlifedata.com/resource/pubmed/id/6891244

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1983-2-25
pubmed:abstractText
Effects of high doses of vitamin D on rat hearts were investigated 72 h after the administration of 500 000 U/kg. Histological examination showed disseminated focal necrosis with reactive round cell and granulocytic infiltration in the heart. The calcium content was increased by about 70%. These findings indicate vitamin D-induced myocardial lesions. Heart mitochondrial calcium binding and uptake activities were lower than in control animals. Na+-K+-ATPase activity of heart washed particles was reduced by the treatment with vitamin D whereas neither calcium binding and uptake activities of cardiac sarcoplasmic reticulum nor myofibrillar ATPase activity were affected. Carbocromen (20 and 100 mg/kg/d) treatment reduced vitamin D-induced decreases in mitochondrial calcium accumulating ability and Na+-K+-ATPase activity of heart washed particle, suggesting a beneficial effect of carbocromen against vitamin D-induced cardiac injury.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1412-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Vitamin D-induced myocardial lesions and the protection by carbocromen.
pubmed:publicationType
Journal Article, In Vitro