Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1983-10-8
|
| pubmed:abstractText |
A series of 9H-xanthen-9-amines possessing a wide variety of nitrogen substituents at C-9 was prepared for evaluation of gastric antisecretory activity. These substituents included the acetamidine, imidate, pyrimidine, thiazoline, quinuclidine, 2-hydrazinopyridine, aminopiperidine, aminoalkylimidazole, and aminoalkylpyridine moieties. The majority of compounds in this series inhibited gastric acid secretion when tested orally in the pylorus-ligated rat. Potency was increased by intraduodenal administration and diminished by incubation with gastric juice, suggesting partial degradation of the compounds in the gastric environment. A representative example, 3-(9H-xanthen-9-ylamino)-1-ethylpiperidine, exhibited similar activity in dogs, although no free compound could be detected in the blood. It is therefore hypothesized that this compound is either rapidly bound to tissue and/or metabolized to an active species.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0022-2623
|
| pubmed:author |
pubmed-author:BenderP EPE,
pubmed-author:EbyR ZRZ,
pubmed-author:GrovesW GWG,
pubmed-author:HostelleyL SLS,
pubmed-author:HwangB YBY,
pubmed-author:KonickiGG,
pubmed-author:LavanchyP GPG,
pubmed-author:LoevBB,
pubmed-author:PerchonockC DCD,
pubmed-author:SchlosserJ HJH,
pubmed-author:SmithR CRCJr,
pubmed-author:SneedRR,
pubmed-author:StringerO DOD,
pubmed-author:WilsonJ WJW3rd
|
| pubmed:issnType |
Print
|
| pubmed:volume |
26
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1218-23
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading | |
| pubmed:year |
1983
|
| pubmed:articleTitle |
Gastric antisecretory 9H-xanthen-9-amines.
|
| pubmed:publicationType |
Journal Article
|