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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1983-10-8
|
| pubmed:abstractText |
Tissue counts in lung, liver, and spleen were not significantly increased in PNC-challenged animals compared to saline-injected controls. In fact, tissue counts from PNC-challenged animals were significantly decreased in heart, kidney, and brain compared to saline-injected controls (P less than 0.05 by Mann-Whitney U test). Tissue radioactivity reflecting intravascular volume can be altered by changes in either tissue perfusion or vascular permeability. PNC sepsis is associated with both cardiovascular dysfunction [1] as well as complement activation with generation of cleavage products known to exert anaphylatoxin activity [2]. We could not demonstrate increased vascular permeability at 3 hr in the lungs or in any of the other five tissues studied. However, it is possible that some degree of increased vascular permeability could be obscured by concomitant tissue hypoperfusion.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
148
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
179
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading | |
| pubmed:year |
1983
|
| pubmed:articleTitle |
Effect of intravascular pneumococcal challenge on vascular permeability in rabbits.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|