Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1983-10-8
|
| pubmed:abstractText |
The responses of congenitally athymic rats to Schistosoma mansoni were compared to thymic reconstituted, heterozygous littermate controls, and inbred Fischer rats. The mechanisms of the impaired resistance of athymic rats to initial exposure and re-exposure to S. mansoni were investigated by the study of various parameters of antibody response. The uninfected athymic animals demonstrated normal levels of total IgM but reduced levels of total IgG2a and IgE. After infection with S. mansoni, the immunoglobulin increases in athymic rats were less than those observed in heterozygote control rats. In addition, the level of anti-S. mansoni IgG antibody, utilizing ELISA assay, was reduced. Furthermore, the functional avidity of the IgG2a antibody, which was produced by the athymic animals, was significantly lower than that of control heterozygote and Fischer animals. Similarly, the levels of IgE and IgG2a anaphylactic antibodies were reduced in the congenitally athymic animals. After thymic reconstitution and exposure to S. mansoni of the congenitally athymic animals, all of these parameters became similar to the analogous value obtained from exposed heterozygous and homozygous animals. In vitro studies of antibody-dependent cell-mediated cytotoxicity (ADCC) activity indicated that the antibody response of the congenitally athymic animals was characterized by significant reductions in IgE-macrophage-mediated, IgG-eosinophil-mediated, and IgE-eosinophil-mediated cytotoxicity directed against schistosomula. These results, coupled with previously reported in vivo observations, that athymic animals produced antibody that was less capable of transferring resistance in adoptive-challenge experiments, suggest that the mechanisms of impaired resistance in the congenitally athymic rat may involve the failure to develop adequate, functional ADCC mechanisms. As such, these studies suggest a relationship between in vivo resistance and possible in vitro mechanisms of that resistance.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
131
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1475-80
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:6886422-Animals,
pubmed-meshheading:6886422-Antibody Specificity,
pubmed-meshheading:6886422-Antibody-Dependent Cell Cytotoxicity,
pubmed-meshheading:6886422-Binding Sites, Antibody,
pubmed-meshheading:6886422-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:6886422-Eosinophils,
pubmed-meshheading:6886422-Immunoglobulin E,
pubmed-meshheading:6886422-Immunoglobulin G,
pubmed-meshheading:6886422-Immunoglobulin M,
pubmed-meshheading:6886422-Immunoglobulins,
pubmed-meshheading:6886422-Macrophages,
pubmed-meshheading:6886422-Passive Cutaneous Anaphylaxis,
pubmed-meshheading:6886422-Rats,
pubmed-meshheading:6886422-Rats, Inbred F344,
pubmed-meshheading:6886422-Rats, Mutant Strains,
pubmed-meshheading:6886422-Schistosoma mansoni,
pubmed-meshheading:6886422-Schistosomiasis
|
| pubmed:year |
1983
|
| pubmed:articleTitle |
Immunologic response of athymic rats to Schistosoma mansoni infection. II. Antibody-dependent mechanisms of resistance.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|