| pubmed-article:6885156 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6885156 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:6885156 | lifeskim:mentions | umls-concept:C0006434 | lld:lifeskim |
| pubmed-article:6885156 | lifeskim:mentions | umls-concept:C1265277 | lld:lifeskim |
| pubmed-article:6885156 | lifeskim:mentions | umls-concept:C0085469 | lld:lifeskim |
| pubmed-article:6885156 | lifeskim:mentions | umls-concept:C0042765 | lld:lifeskim |
| pubmed-article:6885156 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:6885156 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:6885156 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:6885156 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6885156 | pubmed:dateCreated | 1983-10-21 | lld:pubmed |
| pubmed-article:6885156 | pubmed:abstractText | The virulence of Pseudomonas aeruginosa and other pseudomonads was examined in a burned mouse model. P. aeruginosa M-2 was highly virulent causing 100% mortality by 38 h with an injection of 10(2) CFU by either a subcutaneous or intraperitoneal route. Subcutaneous injection of 10(2) CFU revealed rapid multiplication of the bacteria at the burn wound with 10(8) CFU/g detectable in the burned skin by 28 h postinjection, 10(5) CFU/g of liver, and 10(3) CFU/ml of blood. Non-P. aeruginosa clinical isolates were markedly less virulent; an injection of greater than or equal to 10(7) CFU caused less than or equal to 60% lethality. P. cepacia SMH colonized the burned skin of thermally injured mice, persisting at levels of 10(7) to 10(8) CFU/g of burned skin after an initial injection of 10(5) CFU. P. cepacia persisted in the burn wound for at least 3 weeks. No organ invasion was detectable throughout this period. Studies with an additional clinical isolate of P. cepacia yielded similar results. An injection of a 10(2) CFU dose revealed that the level of persistence is dose dependent. Results suggest that the tenacious persistence of P. cepacia in the burn wound may provide a model for the study of persistent colonization and infection in a compromised host. | lld:pubmed |
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| pubmed-article:6885156 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6885156 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6885156 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6885156 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6885156 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:6885156 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:6885156 | pubmed:author | pubmed-author:MontieT CTC | lld:pubmed |
| pubmed-article:6885156 | pubmed:author | pubmed-author:DrakeD RDR | lld:pubmed |
| pubmed-article:6885156 | pubmed:author | pubmed-author:StoverG BGB | lld:pubmed |
| pubmed-article:6885156 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6885156 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:6885156 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6885156 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6885156 | pubmed:pagination | 1099-104 | lld:pubmed |
| pubmed-article:6885156 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6885156 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6885156 | pubmed:articleTitle | Virulence of different Pseudomonas species in a burned mouse model: tissue colonization by Pseudomonas cepacia. | lld:pubmed |
| pubmed-article:6885156 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6885156 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:6885156 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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