Linked Life Data

6884706

Source:http://linkedlifedata.com/resource/pubmed/id/6884706

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-10-21
pubmed:abstractText
Ethinylestradiol, administered to male Wistar rats for 5 days (5 mg/kg X day), decreased bile flow in anesthetized animals and in isolated perfused livers. The bile salt secretion rate was diminished. The bile-to-perfusate ratios of [14C]sucrose and [14C]inulin increased significantly, but this could be attributed to the decline of bile flow as indicated by almost identical clearance rates. Theorectical analysis according to Forker and Wheeler yielded diffusion permeability coefficients (K) for sucrose and inulin of 0.243 and 0.037 in controls and 0.273 and 0.038 in ethinylestradiol-treated rats. In contrast, 9 h of alpha-naphthylisothiocyanate treatment (250 mg/kg) caused cholestasis with heavily decreased bile salt secretion rates. Here, K-values calculated for sucrose and inulin were 0.807 and 0.175. These findings suggest that altered permeability of the paracellular pathway is the cause for alpha-naphthylisothiocyanate-induced cholestasis, but not the primary event in ethinylestradiol-induced cholestasis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0016-5085
pubmed:author
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
808-14
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
No increase of biliary permeability in ethinylestradiol-treated rats.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't