Linked Life Data

6884301

Source:http://linkedlifedata.com/resource/pubmed/id/6884301

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-10-8
pubmed:abstractText
Three-month-old male Wistar rats exposed intermittently (5 days weekly, 6 hr/day) to furfuryl alcohol vapor at 1 (25 ppm), 2 (50 ppm), or 4 mumol/liter (100 ppm) for 4 to 16 weeks were lighter than controls at the end of the experiment at the two higher concentration levels. Urinary furoic acid excretion was in a linear relationship to the exposure at the same time. Analysis for cerebellar creatine kinase showed increased activity in all groups throughout the experiment while succinate dehydrogenase activity decreased in a dose-dependent manner at later time points. Glial cell fractions isolated from cerebral hemispheres showed decreased succinate dehydrogenase activity while 2',3'-cyclic nucleotide 3'-phosphohydrolase activity increased at 4 mumol/liter for 16 weeks. This change was accompanied by decreased basic protein content of isolated myelin fractions. The results indicate that furfuryl alcohol, at fairly low vapor concentrations, may have significant mitochondrial effects in the brain which lead to glial cell degeneration and initiation of demyelination.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0013-9351
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
420-7
pubmed:dateRevised
2006-10-30
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Neurotoxicity of furfuryl alcohol vapor in prolonged inhalation exposure.
pubmed:publicationType
Journal Article