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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1983-10-21
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pubmed:abstractText |
Discrimination between the three clinical subtypes of Gaucher's disease based on the molecular forms of beta-glucocerebrosidase detected by monoclonal antibody is described. In normal fibroblast extracts, cross-reacting material (CRM) to human placental glucocerebrosidase is detected at Mr approximately equal to 63 000, 61 000 and 56 000. In Type 1 Gaucher's disease, the major fibroblast CRM has a Mr approximately equal to 56 000,, with less CRM seen at 61 000 and 56 000. Type 3 fibroblast extracts have a single CRM form at Mr approximately equal to 63 000. No CRM is found in Type 2 Gaucher's disease fibroblasts with monoclonal antiglucocerebrosidase antibody 8E4.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0009-8981
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
283-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6883722-Antibodies, Monoclonal,
pubmed-meshheading:6883722-Fibroblasts,
pubmed-meshheading:6883722-Gaucher Disease,
pubmed-meshheading:6883722-Glucosidases,
pubmed-meshheading:6883722-Glucosylceramidase,
pubmed-meshheading:6883722-Humans,
pubmed-meshheading:6883722-Immunochemistry,
pubmed-meshheading:6883722-Phenotype
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pubmed:year |
1983
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pubmed:articleTitle |
Determination of Gaucher's disease phenotypes with monoclonal antibody.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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