Linked Life Data

6877489

Source:http://linkedlifedata.com/resource/pubmed/id/6877489

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-9-20
pubmed:abstractText
The effects of varying doses of amphetamine on the permeability of the blood-brain barrier (BBB) to albumin were studied in young and aged Fischer 344 rats. There was no change in the permeability of the BBB associated with aging as revealed by saline-treated control experiments. The changes in the permeability of the BBB did not correlate with the changes in blood pressure produced by corresponding doses of amphetamine in the young or aged animals. In the dose range reported the young and aged rats showed similar pressor responses to amphetamine. The aged rats showed a greater increase in the permeability of the BBB than the young, and this effect was seen with a lower dose of amphetamine in the aged rats. At the highest doses tested the permeability was restored to control levels in both the young and the aged rats. The enhanced vulnerability of the BBB of the aged rats may be related to a deterioration of the noradrenergic control of cerebrovascular permeability.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0197-4580
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Age-associated changes in the effects of amphetamine on the blood-brain barrier of rats.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.