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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0001041,
umls-concept:C0001613,
umls-concept:C0001811,
umls-concept:C0007776,
umls-concept:C0022655,
umls-concept:C0030685,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1135598,
umls-concept:C1283071,
umls-concept:C1519355,
umls-concept:C1963578
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pubmed:issue |
1
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pubmed:dateCreated |
1983-9-20
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pubmed:abstractText |
Acetylcholine release from cortical slices superfused with choline-enriched Krebs solution containing physostigmine was investigated at birth, at 7, 20 and 30 days, and at 3 and 24 months of age, in order to assess age influence on the functional efficiency of the cortical cholinergic network. The slices were electrically stimulated at frequencies from 1 to 10 Hz for 5 min periods, preceded and followed by rest periods. The superfusate was collected every 5 min and acetylcholine content quantified by bioassay. In the newborn and 7 day-old pups acetylcholine release was approximately 50% lower than that of the 3 month-old rats at all frequencies tested. The highest release was elicited in the 30 day-old rats. Beginning with this age the evoked ACh release underwent a decline which in the 24 month-old rats brought it back to the same level as in the newborn ones. The blockade of the muscarinic autoreceptors by atropine 1.5 X 10(-8) M caused an increase in acetylcholine release at 20 day, 3 and 24 months of age but not in the newborn and 7 day-old pups. Adenosine 3 X 10(-5) M decreased acetylcholine output in newborn and adult but had no effect in the senescent rats.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0197-4580
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
31-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6877485-Acetylcholine,
pubmed-meshheading:6877485-Aging,
pubmed-meshheading:6877485-Animals,
pubmed-meshheading:6877485-Atropine,
pubmed-meshheading:6877485-Cerebral Cortex,
pubmed-meshheading:6877485-Electric Stimulation,
pubmed-meshheading:6877485-Female,
pubmed-meshheading:6877485-Male,
pubmed-meshheading:6877485-Rats,
pubmed-meshheading:6877485-Rats, Inbred Strains
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pubmed:year |
1983
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pubmed:articleTitle |
Acetylcholine release from rat cortical slices during postnatal development and aging.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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