Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5924
pubmed:dateCreated
1983-9-9
pubmed:abstractText
We have previously shown by X-ray diffraction techniques that the stability of the myelin lattice is decreased by repetitive stimulation of the nerve. We now show that in rat myelinated fibres this structural change is accompanied by the appearance of voltage-sensitive potassium channels which do not normally participate in the generation of the action potential. Since it has previously been shown that structures associated with potassium channels are found in the internodal and paranodal axolemma membrane but are normally concealed under the myelin sheath, we suggest that the acceleration of myelin swelling after repetitive propagation of the action potential may be due to the opening of paranodal axoglial junctions. To our knowledge this is the first demonstration that nerve activity may regulate the structural properties of the paranode.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:volume
304
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
344-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Loosening of paranodal myelin by repetitive propagation of action potentials.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't