Linked Life Data

6875534

Source:http://linkedlifedata.com/resource/pubmed/id/6875534

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-9-20
pubmed:abstractText
Synthetic or natural analogues of the pineal indole, melatonin, were injected separately every evening (1700 hours) for 7 (Exp. 1) or 10 (Exp. 2) weeks into adult male Syrian hamsters maintained in 14 hours of light and 10 hours of darkness each day. Plasma thyroxine (T4) levels were significantly depressed by 25 micrograms/day of melatonin (aMT) in both experiments. Injecting 25 micrograms/day either of acetyl methoxytryptophol or of synthetic analogues (hexanoyl methoxytryptamine, propionyl methoxytryptophol, or 6-chloro-melatonin) in Exp. 1 or of a natural analogue (N-acetylserotonin, 6-hydroxy-melatonin, hydroxytryptophol, or methoxytryptophol) in Exp. 2 had no effect on the circulating T4 levels. Plasma levels of triiodothyronine (T3) and thyrotropin (TSH) were unaffected in either experiment. Since none of the tested melatonin analogues is capable of suppressing circulating T4 concentration when given in a dose at which melatonin is reproducibly effective, the pineal-induced suppression of T4 is most likely mediated by melatonin. Plasma cholesterol levels were elevated only in hamsters receiving 6-chloromelatonin injections. However, plasma triglyceride levels were significantly higher than the diluent treated controls in Exp. 1 after injections of melatonin, acetyl methoxytryptophol, propionyl methoxytryptophol and 6-chloromelatonin. Interscapular brown adipose tissue was significantly heavier in melatonin treated animals.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-9564
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
279-91
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Natural and synthetic analogues of melatonin and related compounds. II. Effects on plasma thyroid hormones and cholesterol levels in male Syrian hamsters.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.