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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1983-9-20
|
| pubmed:abstractText |
Combined oral therapy with digoxin (0.375 mg/dl) and disopyramide (300 and 600 mg/dl) in nine subjects did not alter steady-state digoxin serum concentrations just before the daily single digoxin dose. Digoxin and creatinine clearances were not changed. After a bolus IV dose of 0.8 mg digoxin, volume of distribution (from 672 +/- 176 l to 407 +/- 153 l) and elimination t1/2 beta of digoxin were reduced significantly in five subjects after 600 mg oral disopyramide daily (from 40.2 +/- 11.7 hr to 22 +/- 7.3 hr). Total clearance and digoxin distribution t1/2 alpha did not change significantly. The clinical significance of this interaction is not clear.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0009-9236
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
34
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
176-80
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:6872411-Adult,
pubmed-meshheading:6872411-Creatinine,
pubmed-meshheading:6872411-Digoxin,
pubmed-meshheading:6872411-Disopyramide,
pubmed-meshheading:6872411-Drug Interactions,
pubmed-meshheading:6872411-Humans,
pubmed-meshheading:6872411-Kinetics,
pubmed-meshheading:6872411-Male,
pubmed-meshheading:6872411-Pyridines
|
| pubmed:year |
1983
|
| pubmed:articleTitle |
On the interaction between digoxin and disopyramide.
|
| pubmed:publicationType |
Journal Article
|