Linked Life Data

6872181

Source:http://linkedlifedata.com/resource/pubmed/id/6872181

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3 Pt 2
pubmed:dateCreated
1983-9-20
pubmed:abstractText
An "optimal" technique of vein graft preparation with papaverine and tissue culture was compared with an "injury" technique with 37 degrees C saline storage for 1 hr. Paired interposition cephalic vein grafts were placed in the femoral arteries of dogs. Specimens were taken at the time of implantation, at 3 and 24 hr, and at 7 and 30 days for light, scanning, and transmission electron microscopy. Veins obtained by the injury method showed extensive initial disruption of the endothelium and platelet and white cell adhesion at 3 and 24 hr. At 7 days the endothelium was restored, but there was marked inflammation and neovascularization of the media. At 30 days this had resolved; however, the smooth muscle cells appeared modulated (increase in relative numbers of metabolic organelles with contractile apparatus disassembly). Extracellular matrix was substantially increased, with abundant amorphous ground substance. In contrast, veins obtained by the optimal method had intact endothelium both at implantation and thereafter. Adhesion of white cells and platelets to the endothelium did not occur. The media remained compact without inflammation and without modulation of the smooth muscle cells. We conclude that vein grafts prepared by the optimal technique do not develop early or late evidence of endothelial or medial injury. This should result in a nonthrombogenic graft immediately after surgery and diminished late intimal/medial hyperplasia.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0009-7322
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
II117-24
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Integrity of vein grafts as a function of initial intimal and medial preservation.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.