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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7-8
|
| pubmed:dateCreated |
1983-9-20
|
| pubmed:abstractText |
Cardiac microsomes from rats injected with doxorubicin (5 mg/kg ip x 3) were susceptible to dramatically enhanced NADPH-dependent lipid peroxidation in the presence of doxorubicin in vitro (18-fold increases over control peroxidation). These results suggest that doxorubicin treatment in vivo caused biochemical alterations which predisposed cardiac microsomal membranes to attack by anthracycline free radical-generated oxyradicals.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0361-5960
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
67
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
731-3
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:6871890-Animals,
pubmed-meshheading:6871890-Doxorubicin,
pubmed-meshheading:6871890-Heart,
pubmed-meshheading:6871890-Lipid Peroxides,
pubmed-meshheading:6871890-Male,
pubmed-meshheading:6871890-Microsomes,
pubmed-meshheading:6871890-Myocardium,
pubmed-meshheading:6871890-Rats,
pubmed-meshheading:6871890-Rats, Inbred Strains
|
| pubmed:articleTitle |
Enhancement of rat heart microsomal lipid peroxidation following doxorubicin treatment in vivo.
|
| pubmed:publicationType |
Journal Article
|