Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-9-23
pubmed:abstractText
1 In the rat, administration of dopamine is associated with diuresis, natriuresis and a decreased excretion of K+. The site of action of dopamine in mediating these responses has been investigated. 2 Urine volume, and urinary Na+, K+, Cl- and dopamine concentrations have been measured in adrenalectomized and sham-operated male Wist ar rats. 3 As expected, adrenalectomy decreased urine volume and increased Na+ and Cl- excretion; at the same time the amount of dopamine excreted fell, and K+ excretion did not change. 4 Administration of either 3% NaCl (20 ml/kg orally) or frusemide (100 mg/kg s.c.) significantly elevated dopamine excretion after adrenalectomy. 5 When dopamine, 1, 10 and 30 mg/kg (s.c.) was given to adrenalectomized rats, the diuresis and fall in K+ excretion seen in control animals was still present. No further natriuresis, over and above the already high urinary Na+ levels, was observed. 6 The results show that the three actions of dopamine in inducing diuresis and natriuresis, and decreasing K+ excretion, are clearly separable. 7 It is further argued that in mediating these effects the main site of action of dopamine is the kidney rather than the adrenal gland.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6871536-14171789, http://linkedlifedata.com/resource/pubmed/commentcorrection/6871536-14214434, http://linkedlifedata.com/resource/pubmed/commentcorrection/6871536-28196, http://linkedlifedata.com/resource/pubmed/commentcorrection/6871536-4335169, http://linkedlifedata.com/resource/pubmed/commentcorrection/6871536-438333, http://linkedlifedata.com/resource/pubmed/commentcorrection/6871536-447857, http://linkedlifedata.com/resource/pubmed/commentcorrection/6871536-4554480, http://linkedlifedata.com/resource/pubmed/commentcorrection/6871536-4653587, http://linkedlifedata.com/resource/pubmed/commentcorrection/6871536-53377, http://linkedlifedata.com/resource/pubmed/commentcorrection/6871536-5428909, http://linkedlifedata.com/resource/pubmed/commentcorrection/6871536-551077, http://linkedlifedata.com/resource/pubmed/commentcorrection/6871536-6110748, http://linkedlifedata.com/resource/pubmed/commentcorrection/6871536-671042, http://linkedlifedata.com/resource/pubmed/commentcorrection/6871536-7359426
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
103-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
An investigation of the importance of the adrenal gland to the action of dopamine in the rat kidney.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't