| pubmed-article:6871079 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6871079 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:6871079 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6871079 | lifeskim:mentions | umls-concept:C0003962 | lld:lifeskim |
| pubmed-article:6871079 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:6871079 | lifeskim:mentions | umls-concept:C0001771 | lld:lifeskim |
| pubmed-article:6871079 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6871079 | pubmed:dateCreated | 1983-9-9 | lld:pubmed |
| pubmed-article:6871079 | pubmed:abstractText | Replacement of enriched CMRL 1066 medium by cell-free ascites from tumour patients in the human tumour clonogenic assay described by Hamburger and Salmon (1977) increased plating efficiency for ovarian cancer cells by a median of 8-fold (range 0.4-1012 fold). In 40 experiments, two cases had a lower plating efficiency when cultured in cell-free ascites, 10 grew neither in standard medium nor in cell-free ascites and in two cases, growth was only observed in cell-free ascites. With standard medium, we observed 53% growth (greater than 5 colonies/dish) and 41% evaluable for chemosensitivity testing (greater than 30 colonies/dish). With cell-free ascites as culture medium, these figures were 71% and 63%, respectively. While under standard conditions the highest plating efficiency obtained was 0.25%, in 21% of the experiments done with cell-free ascites a plating efficiency higher than 1% was reached. We conclude that cell-free ascites is able to stimulate proliferation of ovarian cancer cells in agar and that the use of it extends the applicability of the clonogenic assay. | lld:pubmed |
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| pubmed-article:6871079 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6871079 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6871079 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6871079 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6871079 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:6871079 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:6871079 | pubmed:author | pubmed-author:UitendaalM... | lld:pubmed |
| pubmed-article:6871079 | pubmed:author | pubmed-author:PinedoH MHM | lld:pubmed |
| pubmed-article:6871079 | pubmed:author | pubmed-author:McVieJ GJG | lld:pubmed |
| pubmed-article:6871079 | pubmed:author | pubmed-author:HubertH BHB | lld:pubmed |
| pubmed-article:6871079 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6871079 | pubmed:volume | 48 | lld:pubmed |
| pubmed-article:6871079 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6871079 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6871079 | pubmed:pagination | 55-9 | lld:pubmed |
| pubmed-article:6871079 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6871079 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6871079 | pubmed:articleTitle | Human tumour clonogenicity in agar is improved by cell-free ascites. | lld:pubmed |
| pubmed-article:6871079 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6871079 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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