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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1983-9-23
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pubmed:abstractText |
We have investigated the interaction of azapropazone with phenytoin in five healthy volunteers. From steady-state plasma phenytoin concentrations of about 17 mumol/l there was at least a two-fold increase following the introduction of azapropazone. The main mechanism of the interaction was a decrease in phenytoin clearance, attributable to competitive inhibition by azapropazone of phenytoin p-hydroxylation. Protein-binding of phenytoin in the plasma (as assessed by salivary phenytoin concentrations) was significantly reduced from 92 to 90% by azapropazone and similar changes occurred in in vitro studies of [3H]-phenytoin protein binding.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6871071-1261300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6871071-314381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6871071-365209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6871071-383353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6871071-4854723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6871071-6797618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6871071-6803981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6871071-7295492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6871071-7329887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6871071-7379305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6871071-978395
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
727-34
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1983
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pubmed:articleTitle |
Pharmacokinetic investigation of the interaction of azapropazone with phenytoin.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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