Linked Life Data

6864234

Source:http://linkedlifedata.com/resource/pubmed/id/6864234

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-8-26
pubmed:abstractText
The development of human pineal astrocytes was studied in a prospective autopsy series of 115 cases with an age range of 24 weeks of gestation to 91 years. Pineal glands selected from cases with postmortem intervals of one to 24 hours were fixed in Bouin's fluid and immunostained using the peroxidase-antiperoxidase technique and an antiserum against human glial fibrillary acidic (GFA) protein. In adults, scattered, mostly angular and strongly-positive cells and processes were present. A few primary processes emanated from each astrocyte which abruptly subdivided into several secondary ones, creating a pervasive interstitial network of fibers which surrounded almost every individual pinealocyte. Astrocytic endfeet formed a limiting lamina at the periphery of the gland and a barrier between perivascular spaces and the pineal parenchyma. At 24 weeks of gestation, occasional punctate staining, mainly around vessels, was present in the pineal body, while in the surrounding white matter there was already pronounced astrocytic differentiation. Around 32 weeks of gestation, well-formed astrocytes and a weakly staining network of their processes appeared in differentiated areas of the pineal gland. Both astrocytes and their interstitial network of processes became more prominent with advancing age. There was no astrocytic hypertrophy or hyperplasia around calcified deposits. Rosenthal fibers stained negatively for GFA protein. These findings emphasize the significance of the astrocytic participation in the structure of the human pineal gland throughout life.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-3069
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
391-408
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Glial fibrillary acidic (GFA) protein-containing cells in the human pineal gland.
pubmed:publicationType
Journal Article