Linked Life Data

6861722

Source:http://linkedlifedata.com/resource/pubmed/id/6861722

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-8-11
pubmed:abstractText
The Tradescantia-Micronucleus (Trad-MCN) bioassay was utilized to determine the genotoxicity of Malathion, a common insecticide. Four different treatment procedures were applied: a) absorption of Malathion/water mixture (with or without DMSO and/or S-9) through the stem, b) spraying a Malathion/water mixture onto the plant cuttings in enclosed chambers, c) spraying a Malathion/water mixture on an open population of plants in the greenhouse, and d) absorption of Malathion fumes through the leaves and buds. Most treatments were administered for 6 hr, followed by a 24-hr recovery time. Slides were prepared from the samples and scored for micronucleus (MCN) frequencies. Results of 16 experiments indicated that the genotoxicity of liquid Malathion absorbed through the stem was very low and often masked by high toxicity, causing dead cells in the stem, leaves, and meiocytes. Malathion spray at the dosage of 0.435% in an enclosed chamber or on an open population of plants yielded negative responses. Malathion fumes at dosages of 0.15-0.25% induced significantly higher (0.05) MCN frequencies above the controls and altered the nuclear structure to form unequal sized nuclei and multiple breaks in each of the four cells of a tetrads. It also caused degeneration of nuclei, "protrusions on nuclei," and inhibition of cell growth. Higher dosages (above 0.25%) were toxic.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0192-2521
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-37
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Tradescantia-Micronucleus (Trad-MCN) test on the genotoxicity of malathion.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, Non-P.H.S.