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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1978-10-27
|
| pubmed:abstractText |
Physiological and pharmacological studies of hormones, drugs, and neurotransmitters often generate families of sigmoidal dose-response curves. Optimally efficient data analysis should involve simultaneous description of all curves, rather than fitting each one individually. We have developed a general computerized method to describe the dose-response curves in terms of basal and maximal responses, ED50, and curve shape or steepness. This facile method permits rigorous statistical analysis, provides a basis for pooling of information from separate experiments, and allows one to test which characteristics are shared by various curves.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0002-9513
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
235
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
E97-102
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:686171-Binding, Competitive,
pubmed-meshheading:686171-Biological Assay,
pubmed-meshheading:686171-Computers,
pubmed-meshheading:686171-Dose-Response Relationship, Drug,
pubmed-meshheading:686171-Dose-Response Relationship, Immunologic,
pubmed-meshheading:686171-Nucleic Acid Hybridization,
pubmed-meshheading:686171-Radioimmunoassay,
pubmed-meshheading:686171-Statistics as Topic
|
| pubmed:year |
1978
|
| pubmed:articleTitle |
Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.
|
| pubmed:publicationType |
Journal Article
|