Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-8-11
pubmed:abstractText
The capacity of NZB stem cells to proliferate in vivo was evaluated in two systems which required repopulation of peripheral organs. In both types of depletion systems, stem-cell repopulation after cyclophosphamide treatment or adoptive transfer repopulation in lethally irradiated hosts, it was found that NZB stem cells were hyperproliferating. The increase in proliferating cells was most pronounced in the spleens of NZB mice treated with high-dose cyclophosphamide and in lethally irradiated F1 mice reconstituted with NZB T-cell-depleted bone marrow. Thus, upon a stimulus to repopulate, NZB marrow stem cells will hyperproliferate in peripheral organs resulting in an increase in cell number. The abnormality in the marrow cells can be observed in young NZB mice when their marrow cells are in an environment which requires recovery and division.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0008-8749
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
56-67
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:6861213-Animals, pubmed-meshheading:6861213-Autoimmune Diseases, pubmed-meshheading:6861213-Bone Marrow Cells, pubmed-meshheading:6861213-Cell Count, pubmed-meshheading:6861213-Cell Cycle, pubmed-meshheading:6861213-Cell Differentiation, pubmed-meshheading:6861213-Cyclophosphamide, pubmed-meshheading:6861213-Female, pubmed-meshheading:6861213-Hematopoietic Stem Cells, pubmed-meshheading:6861213-Karyotyping, pubmed-meshheading:6861213-Lymphocyte Activation, pubmed-meshheading:6861213-Male, pubmed-meshheading:6861213-Mice, pubmed-meshheading:6861213-Mice, Inbred CBA, pubmed-meshheading:6861213-Mice, Inbred DBA, pubmed-meshheading:6861213-Mice, Inbred NZB, pubmed-meshheading:6861213-Radiation Chimera, pubmed-meshheading:6861213-Spleen, pubmed-meshheading:6861213-Thymus Gland
pubmed:year
1983
pubmed:articleTitle
Comparison of stem-cell recovery in autoimmune and normal strains.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't