Linked Life Data

6860256

Source:http://linkedlifedata.com/resource/pubmed/id/6860256

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-7-15
pubmed:abstractText
The effects of long-term Phenytoin (DPH) administration were studied on the cerebellum Purkinje layer of Sprague-Dawley rats. Histochemical qualitative studies were performed in order to investigate fluorescence patterns linked to degenerative pigment storage and to changes in biogenic amines. Specific tests for Falck's method and the microspectrofluorometric analysis of fluorescent bodies showed: a) an increase in storage lipopigment which, generally referred to in the literature as lipofuscin, partially exhibit a more complex structure due to the simultaneous presence of lipofuscin and ceroids in the same granular body; b) a change in neurotransmitter patterns. This change must be typically related to an altered metabolism of biogenic amines and/or to degenerative phenomena causing the accumulation of biogenic amines in nerve terminals. The morphological and histochemical pictures support the idea of a generalized Purkinje cell damage.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0391-7258
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
45-53
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Fluorescence histochemical patterns of Purkinje cell layer in rat cerebellum after long-term phenytoin administration.
pubmed:publicationType
Journal Article