Linked Life Data

6855907

Source:http://linkedlifedata.com/resource/pubmed/id/6855907

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5918
pubmed:dateCreated
1983-7-29
pubmed:abstractText
Growth and development of haematopoietic cells in vitro require the presence of specific regulatory molecules. Some of these molecular species appear to have a broad specificity, being able to promote the proliferation and differentiation of multipotential cells, as well as megakaryocytic, erythroid and granulocytic-progenitor cells. Such factors are present in medium conditioned by the growth of lectin-stimulated mouse spleen cells or WEHI-3 myelomonocytic leukaemia cells (WEHI-CM). Using WEHI-CM, we and other have been able to obtain permanently growing, non-leukaemic cell lines of a granulocytic or mast cell nature. Significantly, we have found that the factor in WEHI-CM necessary for the growth of these cells has co-purified with the multi-lineage stimulating activity present in WEHI-CM, suggesting that one molecule may be concerned in the development of multiple cell types. We have now used these cells to investigate the mode of action of this haematopoietic cell growth factor and have found that the requirement of this factor for survival and growth may lie in its ability to modulate ATP levels within the cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:volume
303
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
629-31
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Effect of haematopoietic cell growth factor on intracellular ATP levels.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't