Linked Life Data

6855886

Source:http://linkedlifedata.com/resource/pubmed/id/6855886

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5915
pubmed:dateCreated
1983-7-8
pubmed:abstractText
A Y-linked gene(s) is undoubtedly a prerequisite for testicular development in mammals. However, exceptional cases suggest that the mere presence of the Y chromosome or the Y-linked testis-determining gene does not totally control the fate of the bipotential gonad. For example, in the mouse, a major as yet unmapped autosomal locus is necessary for normal testicular development and at least one additional autosomal locus is implicated. We present here a third autosomal sex-determining locus. This dominantly inherited trait, tentatively named T-associated sex reversal (gene symbol Tas), is closely linked to or a part of the T/t complex on chromosome 17 of the mouse. Gonads of chromosomally XY individuals who inherit Tas on the C57BL/6J inbred strain background differentiate as ovaries or ovotestes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
303
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
338-40
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Sex reversal in XY mice caused by dominant mutation on chromosome 17.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.