Linked Life Data

6855196

Source:http://linkedlifedata.com/resource/pubmed/id/6855196

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1983-7-29
pubmed:abstractText
Continuous exposure of newborn C57BL mice to 80% oxygen at normal atmospheric pressure for as many as 6 weeks results in significant pulmonary injury. This injury is reflected morphometrically and morphologically primarily in an increase in the pulmonary interstitial compartment and in pulmonary fibrosis. The fibrotic response is both peribronchiolar and parenchymal. Lowering the oxygen concentration of continuous exposure from 100 to 80% appears to reduce the cellular response of the alveolar lining cells and the bronchiolar mucosa in the newborn lung more than the fibrotic response. This suggests that the most persistent response in the growing lung to supplemental oxygen concentrations at or below 80% will be peribronchiolar and parenchymal fibrosis. These findings would account for the clinically observed reduction of stage II bronchopulmonary dysplasia, yet persistence of chronic bronchopulmonary dysplasia in human infants treated with supplemental oxygen concentrations below 100%.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0023-6837
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
735-48
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Effect of prolonged exposure to 80% oxygen on the lung of the newborn mouse.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.