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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1983-7-8
|
| pubmed:abstractText |
Nine 14 beta-O-acylated grayanotoxins were synthesized by ozonolysis of 14,16-alkylidenegrayanotoxin III. The correlation between positive inotropic potency (PIE) in guinea pigs and physicochemical parameters (Vw, Mw, and Rm50) in 14 14-substituted grayanotoxins were quantitatively analyzed. It became clear that a parabolic relation existed between the bulkiness of the 14-substituents and PIE and that some electronic factor and the hydrophilic-hydrophobic balance would be related to the development of PIE.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
26
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
851-5
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6854587-Animals,
pubmed-meshheading:6854587-Cardiotonic Agents,
pubmed-meshheading:6854587-Diterpenes,
pubmed-meshheading:6854587-Guinea Pigs,
pubmed-meshheading:6854587-Lethal Dose 50,
pubmed-meshheading:6854587-Male,
pubmed-meshheading:6854587-Mathematics,
pubmed-meshheading:6854587-Myocardial Contraction,
pubmed-meshheading:6854587-Ozone,
pubmed-meshheading:6854587-Stimulation, Chemical,
pubmed-meshheading:6854587-Structure-Activity Relationship
|
| pubmed:year |
1983
|
| pubmed:articleTitle |
Quantitative structure-inotropy relationship applied to substituted grayanotoxins.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|