Linked Life Data

6854586

Source:http://linkedlifedata.com/resource/pubmed/id/6854586

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1983-7-8
pubmed:abstractText
Congeneric 4-anilino- and 4-(alkylamino)-2-methylpyrrolo[2,3-d]pyrimidines showed cytokinin and anticytokinin activities, depending on the structure of their 4-substituents, and the antagonistic nature of the latter was established kinetically. The effect of the substituent on these activities was analyzed quantitatively by using physicochemical parameters and regression analysis to give a single, common equation for both the agonists and antagonists. The results indicated that the maximum width of the N4 substituents is an important factor both for binding to the receptor, thus the extent of activity, and for the quality of activity, agonistic or antagonistic. The electron-withdrawing effect and hydrophobicity of the substituents further enhance binding and, thus, activity, irrespective of the quality of the activity. These results coincide with and/or provide evidence for the hypothesis that in hormonal action, agonist binding causes a conformational change of an otherwise inactive receptor to the active form and that antagonists are species that bind similarly to the receptor but do not cause the effective conformational change.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
838-44
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Quantitative aspects of the receptor binding of cytokinin agonists and antagonists.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't