Linked Life Data

6854273

Source:http://linkedlifedata.com/resource/pubmed/id/6854273

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1983-7-29
pubmed:abstractText
Molecular and host range properties of the virulent L10 strain of Semliki Forest virus were compared to those of the avirulent A7 strain. No difference could be detected between the two strains in adsorption, nucleocapsid synthesis, protein synthesis, ratio of 42S:26S RNA, particle infectivity, interferon induction and susceptibility, or defective interfering particle production. A7 showed lower total RNA synthesis than L10 in BHK, G26-24 (oligodendroglioma) and C1300 (neuroblastoma) cells. Cytopathogenicity of A7 was reduced compared to L10 in C1300 cells but not in G26-24 cells. It is concluded that the avirulent A7 strain has similar host range and molecular properties to the neurovirulence mutants M9 and M136, and that demyelination may be produced by a similar mechanism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1317
pubmed:author
pubmed:issnType
Print
pubmed:volume
64 (Pt 6)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1401-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The avirulent A7 Strain of Semliki Forest virus has reduced cytopathogenicity for neuroblastoma cells compared to the virulent L10 strain.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't