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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2-3
|
pubmed:dateCreated |
1983-7-29
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pubmed:abstractText |
Twelve patients having frequent premature ventricular complexes (PVCs) averaging more than 60 per hour received a single 150-mg intravenous dose of pirmenol. Plasma pirmenol concentration declined biexponentially following the infusion and was analyzed according to a two-compartment open model. Following an erratic distribution phase, the terminal elimination half-life ranged from 4.2 to 16.9 hours, with a geometric mean of 7.6 hours. Total body clearance averaged 164 +/- 58 ml/min, and the mean volume of distribution was 1.45 +/- 0.38 liter/kg. Renal clearance averaged 46.6 +/- 21.2 ml/min, representing 30 +/- 10 per cent of total body clearance. Excretion of unchanged drug in the urine averaged 31.8 +/- 8 per cent of the dose. Renal clearance and elimination half-life were correlated (r = -0.61, P less than 0.05). Eight of the 12 patients achieved greater than 95 per cent suppression of PVCs with a duration between 20 minutes and 23 hours. These favorable pharmacokinetics indicate that pirmenol may be a useful addition to the therapy of ventricular arrhythmias.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0091-2700
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
113-22
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6853743-Adult,
pubmed-meshheading:6853743-Aged,
pubmed-meshheading:6853743-Anti-Arrhythmia Agents,
pubmed-meshheading:6853743-Female,
pubmed-meshheading:6853743-Humans,
pubmed-meshheading:6853743-Infusions, Parenteral,
pubmed-meshheading:6853743-Kidney,
pubmed-meshheading:6853743-Kinetics,
pubmed-meshheading:6853743-Male,
pubmed-meshheading:6853743-Metabolic Clearance Rate,
pubmed-meshheading:6853743-Middle Aged,
pubmed-meshheading:6853743-Piperidines
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pubmed:articleTitle |
Disposition of intravenous pirmenol.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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