Linked Life Data

6853723

Source:http://linkedlifedata.com/resource/pubmed/id/6853723

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1983-7-8
pubmed:abstractText
The hypocholesterolemic effect of the hydrophobic surfactant, poloxalene 2930, was studied in the rabbit to determine whether this agent prevents experimentally produced atherosclerosis. Male rabbits were divided into four groups and fed a control diet (group A) or an atherogenic diet (groups B, C, and D) for 10 wk. Diets of groups C and D were supplemented with 0.5 and 1% poloxalene 2930, respectively. Animals in group B developed significantly greater levels of cholesterol in the serum and aorta compared with group A. Addition of poloxalene 2930 to the diets of groups C and D prevented significant elevations in cholesterol concentrations of both serum and aorta compared with group B with values for group D being essentially similar to those observed in group A. Groups C and D also had significant increases of fecal excretion of both neutral fat and neutral steroids as compared with either groups A or B. There were no atherosclerotic lesions of the aortas from group D. Aortas from rabbits in group B had numerous atheromatous plaques while one rabbit each from groups A and C had several very small atheromatous lesions. These results demonstrate that poloxalene 2930 reduces the rise of serum cholesterol in rabbits in response to an atherogenic diet and prevents the development of atherosclerosis. This hypocholesterolemic effect is likely mediated by the effect of this surfactant on the small intestine.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6853723-13428781, http://linkedlifedata.com/resource/pubmed/commentcorrection/6853723-13435243, http://linkedlifedata.com/resource/pubmed/commentcorrection/6853723-14340676, http://linkedlifedata.com/resource/pubmed/commentcorrection/6853723-4117703, http://linkedlifedata.com/resource/pubmed/commentcorrection/6853723-487926, http://linkedlifedata.com/resource/pubmed/commentcorrection/6853723-588583, http://linkedlifedata.com/resource/pubmed/commentcorrection/6853723-6787159, http://linkedlifedata.com/resource/pubmed/commentcorrection/6853723-7065261, http://linkedlifedata.com/resource/pubmed/commentcorrection/6853723-7325240, http://linkedlifedata.com/resource/pubmed/commentcorrection/6853723-7418867, http://linkedlifedata.com/resource/pubmed/commentcorrection/6853723-7435625
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1490-4
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Hydrophobic surfactant treatment prevents atherosclerosis in the rabbit.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't