Linked Life Data

6850096

Source:http://linkedlifedata.com/resource/pubmed/id/6850096

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1983-7-29
pubmed:abstractText
The effect of cytochalasins B or D on the surface topography of mouse neoplastic fibroblasts of L line (detached from glass by trypsin-EDTA solution) or of its LS subline (adapted to the growth in suspension in vitro), as well as on that of Ehrlich's ascites tumor cells was investigated by screening electron microscopy. Incubation of suspended cells with cytochalasin B (2 micrograms/ml) or cytochalasin D (0.2 microgram/ml) for 30-180 min led to the following changes: (I) progressive decrease of the proportion of the cells with a microvillous surface relief and simultaneous increase in the percentage of the cells with a blebbed microrelief; (2) shortening of the microvilli and decrease of their density on the cell surface; (3) appearance of surface areas with a rough folded relief; (4) formation of very large blebs on the LS or L cell surfaces; (5) unusual "polar" distribution of blebs on Ehrlich's tumor and L cells: the blebs were concentrated in one locus on the cell surface. The data show that normal organization of the actin microfilament system in the cell cortex is necessary for formation of the microvilli but not for the blebs.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0365-9615
pubmed:author
pubmed:issnType
Print
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
84-7
pubmed:dateRevised
2008-10-8
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
[Effect of cytochalasins on the surface topography of neoplastic cells in suspension].
pubmed:publicationType
Journal Article, English Abstract