Linked Life Data

6848466

Source:http://linkedlifedata.com/resource/pubmed/id/6848466

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-2-14
pubmed:abstractText
The in vitro uptake of 3H-NE by storage vesicles from the hypothalamus of age-matched spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats has been studied using a new reliable procedure for the isolation of biochemically active storage vesicles. In each of 13 paired studies, done in triplicate, storage vesicles of SHR took up more 3H-NE than those of WKY. (The mean difference was 37% more uptake by SHR.) Electron-microscopic examination of normotensive samples showed a concentration of intact synaptic vesicles; whereas SHR subfractions were composed of fragmented membranes that resembled swollen, distorted vesicles. These findings in the brain tissues of SHR parallel our previous results found in SHR peripheral tissues. Taken together, we interpret the results to indicate that the membranes of synaptic vesicles of SHR are altered structurally and biochemically.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0194-911X
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Enhanced NE uptake by isolated hypothalamic storage vesicles of hypertensive rats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.