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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1983-6-23
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pubmed:abstractText |
Feeding cultured human fibroblasts with cholesterol and 7-dehydrocholesterol resulted in a strong decrease of the in situ degradation of sphingomyelin (about 20 and 40 fold reduction for cholesterol and 7-dehydrocholesterol respectively, at 50 micrograms/ml of medium, and for 24 h incubation). Measurement performed on cell homogenates showed a slight decrease of the sphingomyelinase activity (about 75% of controls), whereas the activities of other lysosomal enzymes (beta glucosaminidase, beta galactosidase) were not significantly affected.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/7-dehydrocholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholestadienols,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Dehydrocholesterols,
http://linkedlifedata.com/resource/pubmed/chemical/Sphingomyelins
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-291X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
112
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
860-5
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading | |
pubmed:year |
1983
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pubmed:articleTitle |
Cholesterol and 7-dehydrocholesterol inhibit the in situ degradation of sphingomyelin by cultured human fibroblasts.
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pubmed:publicationType |
Journal Article
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