Linked Life Data

6847311

Source:http://linkedlifedata.com/resource/pubmed/id/6847311

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-6-10
pubmed:abstractText
Cardiovascular actions of 4(5)-(2,6-dimethylbenzyl)imidazole (MPV-207) and its three alkyl bridge analogues were investigated in urethane-anaesthetized normotensive rats. Intravenous (i.v.) injections of 0.001-0.1 mg/kg of MPV-207 lowered mean arterial pressure (MAP) and heart rate (HR) in a dose-dependent manner. The compound was effective also upon intracerebroventricular (i.c.v.) administration. The hypotensive effect of i.v. injected MPV-207 (5 micrograms/kg) was attenuated by i.c.v. administered yohimbine (100 micrograms/kg), an alpha 2-adrenoceptor antagonist. MPV-295 having an ethano group between the phenyl and imidazole moieties decreased MAP and HR at i.v. doses of 0.03-3 mg/kg, being active also after i.c.v. injection. Extension of the alkyl bridge to the propano group further decreased the hypotensive and bradycardic activity, and the compound having a butano bridge was practically inactive. The results indicate that the extension of the alkyl bridge between the phenyl and imidazole rings reduces the hypotensive and bradycardic activities of the MPV compounds. Furthermore, the hypotensive action of these compounds may be mediated by a central mechanism involving a stimulation of alpha-adrenoceptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0301-4533
pubmed:author
pubmed:issnType
Print
pubmed:volume
261
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
102-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
A comparative study on hypotensive and bradycardic effects of some new imidazole derivatives with possible central mechanism of action.
pubmed:publicationType
Journal Article, Comparative Study