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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1983-6-10
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pubmed:abstractText |
Experiments were done to test the hypothesis that aggregation of human platelets induced by platelet activating factor (PAF) may be mediated by calmodulin-dependent processes. W-7 [N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide], a potent calmodulin antagonist, caused dose-dependent inhibition of PAF induced aggregation of human platelets in vitro. The ED50 for W-7 was 51.5 +/- 9.5 microM (mean +/- SEM). This concentration is known to be platelet calmodulin-specific. These data are consistent with the hypothesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0037-9727
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
172
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
393-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6844347-Adult,
pubmed-meshheading:6844347-Calcium-Binding Proteins,
pubmed-meshheading:6844347-Calmodulin,
pubmed-meshheading:6844347-Dose-Response Relationship, Drug,
pubmed-meshheading:6844347-Humans,
pubmed-meshheading:6844347-Male,
pubmed-meshheading:6844347-Middle Aged,
pubmed-meshheading:6844347-Platelet Activating Factor,
pubmed-meshheading:6844347-Platelet Aggregation,
pubmed-meshheading:6844347-Sulfonamides
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pubmed:year |
1983
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pubmed:articleTitle |
Calmodulin antagonist W-7 inhibits aggregation of human platelets induced by platelet activating factor.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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