Linked Life Data

6843780

Source:http://linkedlifedata.com/resource/pubmed/id/6843780

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-6-23
pubmed:abstractText
Simultaneous recordings of responses of substantia gelatinosa and deep dorsal horn neurones to thermal noxious cutaneous stimulation were made in spinalized cats anaesthetized with urethane/chloralose. Morphine, whether applied iontophoretically in the substantia gelatinosa (50-200 nA) or injected intravenously (1.0-1.5 mg/kg), enhanced the responses of the substantia gelatinosa cells while depressing those of deep cells. Met-enkephalin-amide (50-200 nA) also had similar reciprocal actions. Naloxone counteracted these effects of the agonists. The results support our previous proposal that the opiates facilitate the activity of a substantia gelatinosa system that controls the responses of deep dorsal horn neurones to pain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0028-3908
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
119-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Actions of morphine and met-enkephalin-amide on nociceptor driven neurones in substantia gelatinosa and deeper dorsal horn.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't