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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1983-6-10
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pubmed:abstractText |
The binding of prednisolone to alpha 1-acid glycoprotein (AGP) was determined in vitro by equilibrium dialysis. The effects of temperature, protein concentration, and drug concentration were evaluated. The binding ratio (bound/free) correlated well with protein concentration (r = 0.958) and percent bound ranged from 2 to 12% over high to low prednisolone concentrations at physiologic AGP concentrations (100 mg/dl). Temperature changes did not perturb binding. The non-linear regression estimate of the binding constant (nk) was 4.4 x 10(3) M-1 indicative of both low affinity and low capacity of AGP for prednisolone. Overall, contribution of AGP to the total plasma binding of prednisolone is less than 3% when considered in the competitive protein binding system with transcortin and albumin. Disease induced alterations of AGP concentrations are relatively unimportant regarding plasma protein binding of prednisolone.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-4731
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
191-4
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6843123-Humans,
pubmed-meshheading:6843123-Kinetics,
pubmed-meshheading:6843123-Orosomucoid,
pubmed-meshheading:6843123-Prednisolone,
pubmed-meshheading:6843123-Protein Binding,
pubmed-meshheading:6843123-Serum Albumin,
pubmed-meshheading:6843123-Temperature,
pubmed-meshheading:6843123-Transcortin
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pubmed:year |
1983
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pubmed:articleTitle |
Binding of prednisolone to alpha 1-acid glycoprotein.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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