Linked Life Data

6842304

Source:http://linkedlifedata.com/resource/pubmed/id/6842304

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1983-6-23
pubmed:abstractText
The effect of the quality and quantity of dietary fats on the morphology and function of the immune system of Sprague-Dawley rats fed either 5% mixed fat, 24% saturated fat, 24% polyunsaturated fat, or 24% partially saturated fat was examined. After 2.5 months of dietary treatment high fat groups showed evidence of splenic hyperplasia, however, no consistent morphologic changes were seen in the mesenteric lymph nodes (MLN). Splenocytes from rats fed the 24% polyunsaturated fat diet were cultured in fetal bovine serum (FBS) and had a depressed lymphocyte transformation response, which persisted after 5 months of dietary treatment. Supplementing the culture medium with 10% rat serum altered the transformation response profile, but high fat serum did not have an immunosuppressive effect. MLN lymphocytes from rats fed the 24% partially saturated diet for 2.5 months had an enhanced response to concanavalin A; at five months the response was elevated in the groups fed saturated as well as partially saturated fat diets. These results suggest that the modulating effect of fat on the immune system depends on the duration of feeding, the type of fat consumed and the organ examined.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-3166
pubmed:author
pubmed:issnType
Print
pubmed:volume
113
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
951-61
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The effect of quality and quantity of dietary fat on the immune system.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't