Linked Life Data

6840206

Source:http://linkedlifedata.com/resource/pubmed/id/6840206

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-6-10
pubmed:abstractText
Treatment of cultured hepatocytes with vinblastine resulted in the inhibition of the reformation of biliary spaces (at times earlier than 16 h) or in the disappearance of preformed bile canaliculi (at times later than 24 h) detectable on both the light and electron microscopical level. Concomitantly the preferential localization of leucine aminopeptidase around the lucid biliary spaces was lost without any change in the specific activity of this enzyme. Despite these alterations the performance of the cultured cells (e.g., urea synthesis) was not impaired by the exposure to the drug. The effect of vinblastine was mimicked by colchicine, but not by lumicolchicine, indicating that microtubules might play a role in the structural organization of the biliary pole.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0014-4827
pubmed:author
pubmed:issnType
Print
pubmed:volume
144
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
218-23
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Disappearance of visible bile canaliculi caused by vinblastine in primary cultures of rat hepatocytes.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't