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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1983-6-10
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pubmed:abstractText |
Two closely related but different aminopeptidases from bovine lung have been isolated and characterized. The first aminopeptidase, which removes the N-terminal arginine residue from L-arginyl-L-prolyl-L-proline, bradykinin, and des-[Arg9]-bradykinin, has kininase activity; it has a pH optimum of 8.0, is stimulated by Mn2+, and its molecular weight in dilute buffers is slightly greater than 240,000 daltons. The second aminopeptidase, which converts kallidin to bradykinin, has kinin-converting activity; it has a pH optimum of 6.8, is stimulated by Co2+, and its molecular weight in dilute buffers is 250,000 daltons. The kinin-converting enzyme is blocked from action when the N-terminal penultimate residue is proline.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0013-9432
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
21-31
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6840049-Aminopeptidases,
pubmed-meshheading:6840049-Animals,
pubmed-meshheading:6840049-Cattle,
pubmed-meshheading:6840049-Hydrogen-Ion Concentration,
pubmed-meshheading:6840049-Kinetics,
pubmed-meshheading:6840049-Lung,
pubmed-meshheading:6840049-Manganese,
pubmed-meshheading:6840049-Molecular Weight,
pubmed-meshheading:6840049-Substrate Specificity
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pubmed:year |
1983
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pubmed:articleTitle |
A kininase and a kinin-converting enzyme: two distinct alpha aminoacyl peptide hydrolases from bovine lung.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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