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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1983-5-27
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pubmed:abstractText |
Eighteen drug addicts with left-sided valvular endocarditis requiring operation are reviewed. Gram-positive bacteria were the most common organisms cultured (61%), with Staphylococcus aureus present in 7 of 11 patients. Gram-negative bacteria, exclusively Pseudomonas aeruginosa, were cultured in the remaining 39%. Indications for operation included sepsis (61%), heart failure (78%), and systemic emboli (22%). Abscesses formed in 6 of 11 patients with gram-positive endocarditis, while only one abscess was present with gram-negative endocarditis. Normal valves were infected in 17 of 18 patients (94%). Early surgical mortality (less than 30 days) was 11%. There were major complications in 79% of these patients, including persistent sepsis (50%), valvular dehiscence, prosthetic endocarditis or perivalvular leakage (37%), and mycotic aneurysms (22%). These complications were directly related to a late mortality of 44%, yielding an overall mortality of 50% in the first nine months after operation. Contrary to previous reports of acceptable surgical survival for valvular endocarditis, these data suggest that endocarditis involving the aortic or mitral valve in a drug addict is a highly lethal disease due to the virulence of the organisms, the severity of the complications encountered, and the predisposition to continued addiction.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0003-4975
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
35
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
436-41
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:6838269-Adolescent,
pubmed-meshheading:6838269-Adult,
pubmed-meshheading:6838269-Aortic Valve,
pubmed-meshheading:6838269-Endocarditis, Bacterial,
pubmed-meshheading:6838269-Female,
pubmed-meshheading:6838269-Heart Valve Prosthesis,
pubmed-meshheading:6838269-Humans,
pubmed-meshheading:6838269-Male,
pubmed-meshheading:6838269-Middle Aged,
pubmed-meshheading:6838269-Mitral Valve,
pubmed-meshheading:6838269-Pseudomonas Infections,
pubmed-meshheading:6838269-Staphylococcal Infections,
pubmed-meshheading:6838269-Substance-Related Disorders
|
pubmed:year |
1983
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pubmed:articleTitle |
Valve replacement for left-sided endocarditis in drug addicts.
|
pubmed:publicationType |
Journal Article
|