|
rdf:type |
|
|
lifeskim:mentions |
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|
pubmed:issue |
4
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pubmed:dateCreated |
1983-5-27
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pubmed:abstractText |
The activation of N2-methyl-9-hydroxyellipticinium acetate (4) by a peroxidase--H2O2 system leads to the formation of an omicron-quinone (7a). This omicron-quinone is not directly generated from the starting material but through a quinone imine intermediate (6) which is subsequently oxidized. This reaction is highly dependent on pH values. The omicron-quinone 7a is easily protonated (7b), gives an addition product with methanol (9), and is reduced by cysteine. The omicron-quinone 7b has a rather low inhibitory effect against L1210 leukemia cell multiplication but acts as an electron carrier and dramatically augments the oxygen consumption in xanthine oxidase-NADH and rat liver microsomes-NADPH systems.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-2623
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
26
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
574-9
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pubmed:dateRevised |
2005-10-12
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pubmed:meshHeading |
pubmed-meshheading:6834391-Alkaloids,
pubmed-meshheading:6834391-Animals,
pubmed-meshheading:6834391-Antineoplastic Agents,
pubmed-meshheading:6834391-Cell Division,
pubmed-meshheading:6834391-Ellipticines,
pubmed-meshheading:6834391-Leukemia L1210,
pubmed-meshheading:6834391-Mice,
pubmed-meshheading:6834391-Microsomes, Liver,
pubmed-meshheading:6834391-Oxygen Consumption,
pubmed-meshheading:6834391-Quinones,
pubmed-meshheading:6834391-Spectrophotometry, Ultraviolet
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|
pubmed:year |
1983
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|
pubmed:articleTitle |
omicron-Quinone formation in the biochemical oxidation of the antitumor drug N2-methyl-9-hydroxyellipticinium acetate.
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pubmed:publicationType |
Journal Article
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