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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
4
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|
pubmed:dateCreated |
1983-5-27
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|
pubmed:abstractText |
Combination immunosuppression therapy with long-acting glucocorticoids, cyclosporin-A, and antiserum to rat lymphocytes (ALS) reduced the severity of spontaneous diabetes among BioBreeding/Worcester rats and decreased the frequency of diabetes in susceptible littermates. Combination therapy with glucocorticoids and three injections of ALS reversed hyperglycemia in a significant number of acutely diabetic animals. These results strengthen the hypothesis that autoimmunity plays a role in the pathogenesis of diabetes in these animals and increase our understanding of the requirements of treatment protocols for the prevention and cure of this spontaneous syndrome.
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pubmed:grant |
|
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Apr
|
|
pubmed:issn |
0012-1797
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:volume |
32
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
326-30
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|
pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6832488-Animals,
pubmed-meshheading:6832488-Antilymphocyte Serum,
pubmed-meshheading:6832488-Blood Glucose,
pubmed-meshheading:6832488-Cyclosporins,
pubmed-meshheading:6832488-Diabetes Mellitus,
pubmed-meshheading:6832488-Drug Therapy, Combination,
pubmed-meshheading:6832488-Immunosuppression,
pubmed-meshheading:6832488-Methylprednisolone,
pubmed-meshheading:6832488-Rats,
pubmed-meshheading:6832488-Rodent Diseases
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|
pubmed:year |
1983
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|
pubmed:articleTitle |
Spontaneous diabetes mellitus in the BB/W rat. Effects of glucocorticoids, cyclosporin-A, and antiserum to rat lymphocytes.
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|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
