Linked Life Data

6831650

Source:http://linkedlifedata.com/resource/pubmed/id/6831650

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 2
pubmed:dateCreated
1983-5-27
pubmed:abstractText
Cardiac hemodynamics, diameter, blood flow velocity, and volumic flow of the brachial artery were studied before and after diltiazem administration in 11 patients with sustained essential hypertension. The study was compared with the hemodynamic effects of dihydralazine. The caliber of the brachial artery was evaluated with a pulsed Doppler velocimeter enabling the determination of the angle between the ultrasound beam and the vessel axis with a precision of 2%. After bolus administration of diltiazem, blood pressure and total peripheral resistance significantly decreased (P less than 0.001) while cardiac index and heart rate significantly increased (P less than 0.01). After 25 minutes of perfusion, cardiac output and heart rate returned toward control values, while blood pressure and total peripheral resistance remained decreased. The results contrasted with those observed after dihydralazine, which induced a sustained increase in cardiac index and heart rate. The caliber of the brachial artery decreased significantly (P less than 0.001) after dihydralazine and increased significantly after diltiazem (P less than 0.01). The study provided evidence that the antihypertensive effect of diltiazem was due to a fall in total peripheral resistance, associated with a transient baroreflex mediated tachycardia, and that--in addition to their effects on small arteries--vasodilating drugs may either increase (diltiazem) or decrease (dihydralazine) the caliber of peripheral large arteries.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0009-7330
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
I169-73
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Hemodynamic effects of diltiazem in hypertension.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't