Linked Life Data

6831394

Source:http://linkedlifedata.com/resource/pubmed/id/6831394

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-5-5
pubmed:abstractText
Addition of the tumor promotor 12-O-tetradecanoyl phorbol-13-acetate (TPA) to serum-deprived mouse 3T3 cells resulted in an increase in ornithine decarboxylase activity which is maximal at 3 h and declined thereafter. Addition of serum to these same cells resulted in an ornithine decarboxylase (ODC) response which was identical to the TPA-induced response at 3 h but continued to increase to a maximum at 6 h. A variant line of 3T3 cells, which possessed phorbol ester receptors, failed to increase its ODC in response to TPA. Also, the early component of the serum-induced ODC response was markedly diminished. These data suggest that phorbol ester tumor promoters may induce an early component of a more extensive ODC response, and that a component of serum may act through the same pathway as the phorbol esters.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0304-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
215-20
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The effects of serum and phorbol ester tumor promoter on ornithine decarboxylase activity in Swiss 3T3 cells.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.