Linked Life Data

6831236

Source:http://linkedlifedata.com/resource/pubmed/id/6831236

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-5-27
pubmed:abstractText
Trophic interactions during development of brain regions were examined in rats using intraocular grafts of central nervous tissue. The increase in volume of transplanted fetal parietal cerebral cortex, as measured through the cornea, was markedly augmented by the presence of several different previously grafted CNS areas such as locus coeruleus, tectum, or cerebral cortex. DNA measurements and histological examinations suggested that this increased volume was due both to hyperplasia and hypertrophy. Previous grafts of iris, in contrast, did not significantly alter the final size of subsequently grafted cortex pieces. Contact between the two transplants was found to be critical in eliciting the trophic response. Growth-stimulated cortical grafts had a better organized cyto-architecture with larger neurons, including typical pyramidal cells, more neuropil, a lower cell density, and a more organotypic distribution of the cell bodies than non-stimulated controls. The experiments thus demonstrate a profound effect of adjacent neural tissue on development of neocortex. It is concluded that trophic interactions upon brain development can be revealed by sequential intraocular grafting.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:volume
282
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
131-40
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Trophic effects of brain areas on the developing cerebral cortex: I. Growth and histological organization of intraocular grafts.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't