Linked Life Data

6830775

Source:http://linkedlifedata.com/resource/pubmed/id/6830775

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-5-5
pubmed:abstractText
We have studied the effect of phloretin, a compound known to interfere with carrier mediated transport processes, on the functional responsiveness of rabbit neutrophils. Phloretin was found to inhibit neutrophil degranulation, aggregation and calcium uptake stimulated by the chemotactic peptide fMet-Leu-Phe. Part of these effects of phloretin may be accounted for by its interference with the binding of the synthetic peptide to its plasma membrane receptors. However, phloretin also inhibits the arachidonic acid and leukotriene B4 induced calcium uptake. These results imply that phloretin affects a component of membrane structure which is central to the activation sequences available to the neutrophils. The results of the present experiments demonstrate that phloretin can interfere with stimulus-response coupling in soluble mediator ('hormone') responsive cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
728
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
97-102
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Phloretin is a potent inhibitor of rabbit neutrophil activation by chemotactic factors.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.