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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1983-5-5
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pubmed:abstractText |
The differential sensitivities of A beta, A delta and C fibres of rat vagus nerve to bupivacaine, etidocaine and AL-381 were studied in vitro. In A beta fibres, at 35-37 degrees C, 50 mumole litre-1 of the drugs had similar effects on the action potential amplitude, while at greater concentrations (100 and 200 mumole litre-1) the greatest mean depression of amplitude was seen with etidocaine (n.s.). AL-381 had the most marked effect on the A delta potentials, and it appeared that it was about twice as potent as the others in blocking these fibres. Etidocaine 100 mumole litre-1 was more depressant than the same dose of bupivacaine. The C fibres were blocked most rapidly by AL-381, while etidocaine had the least effect.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
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pubmed:issn |
0007-0912
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
163-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6830678-Action Potentials,
pubmed-meshheading:6830678-Amides,
pubmed-meshheading:6830678-Anesthetics, Local,
pubmed-meshheading:6830678-Animals,
pubmed-meshheading:6830678-Bupivacaine,
pubmed-meshheading:6830678-Etidocaine,
pubmed-meshheading:6830678-Nerve Block,
pubmed-meshheading:6830678-Nerve Fibers,
pubmed-meshheading:6830678-Nerve Fibers, Myelinated,
pubmed-meshheading:6830678-Phrenic Nerve,
pubmed-meshheading:6830678-Rats,
pubmed-meshheading:6830678-Rats, Inbred Strains,
pubmed-meshheading:6830678-Vagus Nerve
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pubmed:year |
1983
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pubmed:articleTitle |
Differential sensitivity of A and C nerve fibres to long-acting amide local anaesthetics.
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|